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1st to Die by James Patterson is the first book in the Women's Murder Club series, following four San Francisco women—a homicide inspector, a medical examiner, an assistant D.A., and a crime reporter—as they team up to catch a serial killer preying on newlyweds. The friends pool their unique skills to work around their bosses and solve the complex case, which features a shocking conclusion. The novel also introduces Inspector Lindsay Boxer's personal health crisis, adding another layer of personal drama to the thriller.

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