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Inside the O'Briens by Lisa Genova follows Boston cop Joe O'Brien and his Irish-American family after he's diagnosed with Huntington's disease (HD), a fatal, genetic neurodegenerative disorder, forcing his four adult children to confront their own 50/50 chance of inheriting it and deciding whether to get tested, exploring themes of love, fate, resilience, and finding purpose amidst devastating uncertainty, primarily through the eyes of his youngest daughter, Katie.

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